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Water as a Factor in the Photoinactivation of Vaccinia Virus

The Lister Institute of Preventive Medicine, Elstree, Hertfordshire

High concentrations of glycerol and glucose decreased the rate of photo-inactivation of vaccinia virus by methylene blue. These results could not be attributed to changes in the viscosity of the medium or to the impairment of the initial dye sensitization of the virus. Inhibition of photoinactivation by glycerol was not wholly dependent on O₂ concentration. Lyophilization of dye-sensitized virus prevented its subsequent inactivation by exposure to light. These results are interpreted as indicating that water is involved in the photo-inactivation process, although its role is as yet obscure.

Received 15 July 1966; accepted 19 September 1966.