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The Virus of Molluscum Contagiosum and its Adsorption to Mouse Embryo Cells in Culture

Department of Bacteriology, University of Aberdeen, Foresterhill, Aberdeen, Scotland

W. Hodgkiss

Ministry of Technology, Torry Research Station, Aberdeen, Scotland

Earlier work suggested that the antiviral activity in extracts from lesions of molluscum contagiosum was due to the molluscum virus present. This has now been supported by showing a direct relationship between inhibitory activity and electron microscopically determined virus particle count in extracts from 14 patients. Using this antiviral activity as a biological marker, an analysis of the adsorption of the molluscum virus to mouse embryo cell monolayers was made. In general, the pattern of adsorption of the molluscum agent, with respect to time, temperature and inoculum volume, was similar to that already recorded in the literature for adsorption to cell cultures of the infectivity of vaccinia virus. There was a short delay between adsorption of molluscum virus and the onset of challenge virus plaque inhibition. There-after inhibition increased progressively for several hours.

Received 26 September 1966; accepted 24 January 1967.