J Gen Virol
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J Gen Virol 1 (1967), 291-296; DOI 10.1099/0022-1317-1-3-291
© 1967 Society for General Microbiology
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The Inhibition of Polyoma Antigen Synthesis and Capsid Formation by 5-fluorodeoxyuridine

P. Urbano*

Institute of Virology, University of Glasgow, Scotland

In mouse embryo cells infected with polyoma virus, inhibition of DNA replication by fluorodeoxyuridine (10 µM) suppressed the production of haemagglutinin, infectious virus and viral antigen as judged by direct immunofluorescence. No virus-like particles were detected in extracts of inhibited cultures examined by electron microscopy.

* Present address: Istituto di Microbiologiá, Universita di Firenze, Florence, Italy.

Received 14 December 1966; accepted 24 February 1967.




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