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The Mechanism of Viral Carcinogenesis by DNA Mammalian Viruses: DNA-DNA Homology Relationships Among the ‘Weakly’ Oncogenic Human Adenoviruses

Institute for Molecular Virology, Saint Louis University School of Medicine, Saint Louis, Missouri 63110, U.S.A.

Hybridization reactions between the DNAs of the six members of the ‘weakly’ oncogenic adenovirus group (types 3, 7, 11, 14, 16 and 21) show that they are closely related to each other, sharing 70 to 100% of their nucleotide sequences. The ‘weakly’ oncogenic adenoviruses are but distantly related to ‘strongly’ oncogenic types 12 and 18, showing only 11 to 22% homology. Thus, two groups of oncogenic adenoviruses exist, differing remarkably in nucleotide sequence as well as in base composition and degree of oncogenicity.

^* Present address: Departments of Biology, Marymount College, Palos Verdes Estates, California 90275, and Loyola University of Los Angeles, California 90045, U.S.A.

Received 21 February 1967; accepted 19 April 1967.