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Department of Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
Arginine is essential for the replication of herpes simplex virus. Omission of arginine from the culture medium did not affect the synthesis of viral DNA but prevented the formation of virions. Addition of arginine immediately stimulated protein synthesis which was followed by virus formation.
Received 25 May 1967;
accepted 3 June 1967.
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