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Comparison of Interferon Induction by Active and Inactive Semliki Forest Virus

Department of Immunology and Medical Microbiology, College of Medicine, University of Florida, Gainesville, Florida 32601

Semliki Forest virus, inactivated by incubation at 37°, induced considerably more interferon than did the live virus. Infection by live virus produced an earlier termination of interferon synthesis (at 8 hr) which correlated with a profound inhibition of cellular RNA synthesis. Heat-inactivated Semliki Forest virus did not inhibit cellular RNA synthesis until much later and permitted continuation of interferon synthesis for an additional 4 hr, thereby increasing the yield of interferon by about four- to sixfold.

Received 4 August 1970; accepted 16 September 1970.