HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pilch, D. J. F. Articles by Planterose, D. N. Search for Related Content PubMed PubMed Citation Articles by Pilch, D. J. F. Articles by Planterose, D. N. Agricola Articles by Pilch, D. J. F. Articles by Planterose, D. N.

Effects on Friend Disease of Double-stranded RNA of Fungal Origin

Beecham Research Laboratories, Brockham Park, Betchworth, Surrey

This paper reports the effects of treatment with double-stranded RNA of Friend disease, a virus-induced murine leukaemia. The salient feature of the disease is a progressive increase in spleen size; death normally results from rupture of the spleen. It was found that the effect of treatment with double-stranded RNA was closely related to the time of treatment relative to infection. Treatment before or in the early stages of infection increased the severity of the disease, but treatment 5 days after infection led to a profound reduction in the severity of the disease, judged by a pronounced reduction or abolition of splenomegaly. Histological examination of this reversal of splenomegaly showed reduction of the Friend cell infiltration and a return to a more normal spleen architecture. Mice in which remissions have been produced have remained free of evidence of splenomegaly for several weeks. The nature of this therapeutic effect is unknown.

Received 21 April 1970; accepted 12 October 1970.