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Propagation and Cytopathogenicity of Arboviruses in Mouse Embryo Cell Culture

Virus Research Laboratory, University of Ibadan, ^* Ibadan, Nigeria

Thirty-five strains of arbovirus were tested for replication in mouse embryo cell cultures; twenty-six of these multiplied and were cytopathogenic. Dengue 1 and dengue 2 may have multiplied without cytopathogenicity. Twenty-three of the viruses were also tested for the production of complement-fixing antigen; twenty-two were positive. Similar end-points were attained using standard inoculum doses in both tubes and mice for parallel titrations of selected viruses. A major advantage of mouse embryo cell cultures is their ready accessibility to all arbovirus laboratories.

^* The Virus Research Laboratory is financed by the Rockefeller Foundation.

Received 14 August 1970; accepted 13 October 1970.