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The Influence of Inhibitors of Macromolecular Syntheses on Capacity of Herpes Simplex Virus to Induce Chromosomal Damage

Institute of Experimental Biology and Genetics, Czechoslovak Academy of Sciences, Prague 6, Czechoslovakia

When either actinomycin D or puromycin is added to cell cultures at the time of infection with herpes simplex virus, or 1 hr later, there is an inhibition of chromosomal damage induced by virus. On the other hand, cytosine arabinoside considerably potentiates the capacity of herpes simplex virus to induce chromosomal damage. This finding supports the view that chromosomal changes induced by virus are probably due to the action of early enzymes controlled by virus genes.

^* Permanent address: Microbiological Institute of the Medical School, Debrecen, Hungary.

Received 22 May 1970; accepted 13 November 1970.