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J Gen Virol 12 (1971), 59-63; DOI 10.1099/0022-1317-12-1-59
© 1971 Society for General Microbiology
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The Formation and Nature of Foci Induced by a Modified Sarcoma Virus in Human Cells

P. J. Fischinger* and Carolyn O. Moore

Viral Leukaemia and Lymphoma Branch National Cancer Institute National Institutes of Health, Bethesda, Maryland 20014

Murine sarcoma virus (MSV), which in its natural state is enveloped in a murine leukaemia virus coat, can, under select conditions of aggregation with feline leukaemia virus (FelLV), be made to infect and transform cat embryo cells (Fischinger & O'Connor, 1969). The product of such an infection is a new FelLV pseudotype of sarcoma-MSV (FelLV) which replicates to a high titre in cat cells, possesses a new host range, and is neutralized by FelLV antisera (Fischinger & O'Connor, 1969; Sibal et al. 1970). The infectious capacity of MSV (FelLV) is not limited to cat cells but is also manifest by a morphological transformation of cultured human, dog and pig cells (O'Connor & Fischinger, 1970; Chapman, Fischinger & O'Connor, 1970). The MSV infection of mouse cells is defective in the sense that both focus formation and progeny virus replication are only initiated by an infection of a cell with both MSV and murine leukaemia virus (Hartley & Rowe, 1966; Bassin et al. 1968; O'Connor & Fischinger, 1968).

* Present address: Max-Planck-Institut für Virusforschung, Biologisch-medizinische Abteilung, 74 Tübingen, W. Germany.

Received 21 December 1970; accepted 23 March 1971.




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Copyright © 1971 by the Society for General Microbiology.