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Inhibition of Host-specific DNA and RNA Synthesis in KB Cells Following Infection with Frog Virus 3

Groupe de Recherches sur la Pathogénie des Infections Virales de l'I.N.S.E.R.M. Laboratoire de Virologie, 3, rue Koeberlé, 67-Strasbourg, France

In KB cells infected with frog virus 3 at 37°, a non-permissive temperature for frog virus 3, there was a marked inhibition of host-cell RNA and DNA synthesis shortly after infection. The inhibition, which was as effective with gamma-irradiated or heat-inactivated virus as with live frog virus 3 was dependent upon the multiplicity of infection with frog virus 3. The effect of frog virus 3 could not be abolished by chemical inhibitors of protein and RNA synthesis. These findings suggested that a component of the virus particle was responsible for the inhibition of host-cell RNA and DNA synthesis.

Received 8 March 1971; accepted 28 April 1971.