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Virus RNA and Protein Synthesis in Cells Infected with Different Strains of Newcastle Disease Virus

A. Meager

D. C. Burke

Department of Biochemistry, Marischal College, University of Aberdeen
^* Veterinary Medical Research Institute of the Hungarian Acadamy of Sciences, Budapest, Hungary
Division of Biological Sciences, University of Warwick, Coventry CV4 7AL, Warwickshire

The virus RNAs and proteins synthesized in chick embryo cells infected with different strains of Newcastle disease virus have been characterized by polyacrylamide gel electrophoresis. By comparison of the rates of electrophoretic mobility of virus RNA with those of RNA molecules of known molecular weight, the molecular weights were estimated to be 4.8 x 10⁶ for the virus particle RNA and 2.5 x 10⁶, 1.1 x 10⁶ and 0.4 to 0.7 x 10⁶ for the RNA molecules synthesized in infected cells, the latter being heterogeneous. Synthesis of a number of virus particle proteins was readily detected.

Received 27 January 1971; accepted 3 June 1971.