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Differential Susceptibility to Herpes Simplex Viruses of Hamster Cell Lines Established after Exposure to Chemically Inactivated Herpesvirus

Department of Microbiology, College of Medicine, The Milton S. Hershey Medical Centre of The Pennsylvania State University, Hershey, Pennsylvania 17033, U.S.A.

The replication of herpes simplex virus type 1 and herpes simplex virus type 2 was studied in two isolated hamster cell lines. These lines developed after being treated with herpes simplex virus type 2 inactivated with 7,12-dimethylbenz(a)-anthracene. One cell line that developed, HDC-22, had a hypodiploid chromosome number and was missing a D-group chromosome. Growth studies revealed that this cell line did not support the replication of herpes simplex virus type 2 but did support the replication of herpes simplex virus type 1. The other cell line, HDC-17, had a normal karyotype and proved susceptible to both herpes simplex virus type 1 and herpes simplex virus type 2. These hamster cell lines afford an opportunity to study specific resistance to herpes simplex virus and the differences in the replicative cycles of type 1 and type 2 herpesviruses.

Received 18 June 1971; accepted 19 July 1971.