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Antivirus Action of Acrolein, Glutaraldehyde and Oxidized Spermine

Institute of Microbiology, Hebrew University — Hadassah Medical School, Jerusalem, Israel

The inactivation of bacteriophages and myxoviruses by oxidized spermine, acrolein and glutaraldehyde has been studied. Oxidized spermine inactivated T5 and not T2 coliphages, while acrolein was more effective against T-even phages. Myxoviruses also differed in their sensitivity to the various aldehydes. This was determined by plaque counting or by assaying the haemagglutination activity after propagation in embryonated eggs.

High-molecular (condensation?) products, which were formed when spermine was oxidized for several hours by small quantities of enzyme also inactivated viruses.

These experiments stress the uniqueness of oxidized spermine as a virucidal agent, and do not support the hypothesis that its antivirus activity is due to the formation of acrolein as a spontaneous degradation product.

Received 31 March 1971; accepted 23 July 1971.