HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gandhi, S. S. Articles by Burke, D. C. Search for Related Content PubMed Articles by Gandhi, S. S. Articles by Burke, D. C. Agricola Articles by Gandhi, S. S. Articles by Burke, D. C.

Abortive Infection of L Cells by Fowl Plague Virus: Comparison of RNA and Protein Synthesis in Infected Chick and L Cells

D. C. Burke

Division of Biological Sciences, Warwick University, Coventry CV4 7AL, Warwickshire

When L cells were infected with fowl plague virus, virus haemagglutinin, neuraminidase and complement-fixing antigen, but no infectious virus, were produced. Comparison with infection of chick cells showed that, in both cases, there was an early period of sensitivity to actinomycin and that infection caused depression of host-cell protein synthesis. There was no difference in the distribution of newly synthesized virus RNA between the nucleus and cytoplasm in both chick cells and L cells, and all the virus proteins synthesized in chick cells were also synthesized in L cells. However, the two proteins found in the nucleus did not appear to move out of the nuclei of L cells.

^* Present address: School of Microbiology, University of Melbourne, Parkville, Victoria 3052, Australia.

To whom inquiries should be directed.

Received 15 June 1971; accepted 23 July 1971.