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J Gen Virol 13 (1971), 455-462; DOI 10.1099/0022-1317-13-3-455
© 1971 Society for General Microbiology

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A Dominant Epistatic Gene which Inhibits Cellular Susceptibility to RSV(RAV-O)

L. N. Payne and P. K. Pani

Houghton Poultry Research Station, Houghton, Huntingdon

R. A. Weiss*

Department of Anatomy and Embryology, University College London, Gower Street, London, W.C.1

The susceptibility to infectious RSV(RAV-O) of pure-bred and incross-bred chick embryos from the inbred Reaseheath C and I lines was studied, and a genetic hypothesis is proposed to explain the observed segregation of susceptible and resistant embryos. The results suggest (1) the presence of a dominant autosomal gene for susceptibility to RSV(RAV-O), designated es, in the 1 line, and of its recessive allele, es, in the C line, and (2) the presence in the 1 line of an unlinked dominant, autosomal epistatic gene Ie, which inhibits the expression of es, and of its recessive allele, ie, in the C line. The two loci are designated ‘tumour virus e (tve)’ and ‘inhibitore (Ie)’.

* Present address: Department of Microbiology, University of Southern California School of Medicine, 2025 Zonal Avenue, Los Angeles, California 90033, U.S.A.

Received 15 June 1971; accepted 6 August 1971.


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