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Houghton Poultry Research Station, Houghton, Huntingdon
Department of Anatomy and Embryology, University College London, Gower Street, London, W.C.1
The susceptibility to infectious RSV(RAV-O) of pure-bred and incross-bred chick embryos from the inbred Reaseheath C and I lines was studied, and a genetic hypothesis is proposed to explain the observed segregation of susceptible and resistant embryos. The results suggest (1) the presence of a dominant autosomal gene for susceptibility to RSV(RAV-O), designated es, in the 1 line, and of its recessive allele, es, in the C line, and (2) the presence in the 1 line of an unlinked dominant, autosomal epistatic gene Ie, which inhibits the expression of es, and of its recessive allele, ie, in the C line. The two loci are designated tumour virus e (tve) and inhibitore (Ie).
* Present address: Department of Microbiology, University of Southern California School of Medicine, 2025 Zonal Avenue, Los Angeles, California 90033, U.S.A.
Received 15 June 1971;
accepted 6 August 1971.
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