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Defective Virus RNA Synthesis and Production of Incomplete Influenza Virus in Chick Embryo Cells

Department of Medical Microbiology and Immunology, School of Medicine, University of California, Los Angeles, California 90024

Virus particles released from chick embryo cells infected with equine influenza virus at high multiplicity in the first 10 hr after infection contained the complete RNA component of infectious virus. Virus released later (20 to 30 hr after infection) was of von Magnus type and contained the RNAs of incomplete virus. It is concluded that the formation of von Magnus virus in chick embryo cells is due to a defective synthesis of virus RNA components and not due to a defective assembly and release of virus particles.

Received 11 May 1971; accepted 13 September 1971.