HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correction (v16,pNP) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kaluza, G. Articles by Rott, R. Search for Related Content PubMed PubMed Citation Articles by Kaluza, G. Articles by Rott, R. Agricola Articles by Kaluza, G. Articles by Rott, R.

Inhibition of the Multiplication of Enveloped RNA-viruses by Glucosamine and 2-Deoxy-D-Glucose

Institut für Virologie, Justus Liebig-Universität, Giessen, Germany

Glucosamine inhibited the formation of infectious fowl plague, Sindbis, and Semliki Forest virus but had little or no effect on the multiplication of vesicular stomatitis, Newcastle disease, and polio virus. 2-deoxy-D-glucose had a somewhat stronger effect than glucosamine. Only the production of virus glycoproteins seemed to be affected. Almost normal amounts of virus RNA and RNA polymerase were synthesized, and RNP-antigen activities reached control levels. After infection with fowl plague virus the nuclei and cytoplasm of cells incubated with glucosamine showed brilliant staining with fluorescent antibodies against RNP-antigen, whereas haemagglutinin-specific fluorescence was visible weakly in the cytoplasm. The virus-induced alterations of the cell surface, as measured by the agglutinability with Concanavalin A, were abolished by glucosamine.

Received 7 September 1971; accepted 28 October 1971.