HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tevethia, S. S. Articles by McMillan, V. Search for Related Content PubMed PubMed Citation Articles by Tevethia, S. S. Articles by McMillan, V. Agricola Articles by Tevethia, S. S. Articles by McMillan, V.

Detection of Early Cell Surface Changes in Herpes Simplex Virus Infected Cells by Agglutination with Concanavalin A

Department of Virology and Epidemiology Baylor College of Medicine, Houston, Texas 77025 U.S.A.

Changes in the cell membranes after infection or transformation of cells by oncogenic viruses have been demonstrated using a plant agglutinin, Concanavalin A (Con. A) isolated from Jack beans. Upon infection or transformation of cells by oncogenic viruses, the cells agglutinate in the presence of Con. A (Inbar & Sachs, 1969; Ben-Bassat, Inbar & Sachs, 1970; Benjamin & Burger, 1970). Moore & Temin (1971) reported a lack of correlation between transformability by RNA tumor viruses and agglutinability of cells by Con. A. Recent evidence (Cline & Livingston, 1971; Ozanne & Sambrook, 1971; Arndt-Jovin & Berg, 1971; Inbar, Ben-Bassat & Sachs, 1971) has suggested that both normal and transformed cells have the same number of Con. A binding sites but agglutinate differentially to a given concentration of Con. A. Nicolson (1971) showed that single Con. A binding sites at the surface of normal cells are randomly distributed whereas in transformed cells the Con. A sites are present in clusters.

Received 24 September 1971; accepted 10 January 1972.