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Evidence for a New Type-specific Structural Antigen of the Influenza Virus Particle

World Influenza Centre National Institute for Medical Research, Mill Hill, London NW7 1AA

Three virus-coded structural antigens of the influenza virus have been previously described. The ribonucleoprotein (RNP) antigen, identified as the ‘soluble’ antigen of influenza by Hoyle & Fairbrother (1937), is located internally in the virus particle and is antigenically invariant and type-specific, providing the basis for the division of influenza viruses into types A, B and C. The haemagglutinin and neuraminidase antigens occur at the virus surface and are immunologically and morphologically (Laver & Valentine, 1969) distinct proteins which show a considerable degree of antigenic variation. In addition, Dimmock & Watson (1969) have presented evidence for a non-structural antigen induced by the influenza virus which appeared to be present in the nucleoli of cells early after infection with influenza. This report describes studies on an additional antigen of the virus which appears to be located internally in the particle.

Received 13 December 1971; accepted 11 January 1972.