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J Gen Virol 15 (1972), 171-174; DOI 10.1099/0022-1317-15-2-171
© 1972 Society for General Microbiology
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Hybridization Studies with Subtypes and Mutants of Foot-and-Mouth Disease Virus Type O

B. Dietzschold, O. R. Kaaden and R. Ahl

Bundesforschungsanstalt für Viruskrankheiten der Tiere, Postfach 1149 Tübingen, W. Germany

Seven serologically and immunologically distinct types of foot-and-mouth disease virus (FMDV) are known; these types can be subdivided into numerous subtypes. Recently, we reported on polynucleotide sequence homologies among the ribonucleic acids (RNA's) of FMDV types A, O and C (Dietzschold et al. 1971). Making use of saturation and competition experiments various degrees (44 to 65%) of base sequence homologies between different types were obtained. This report is concerned with similar studies but using subtypes and mutants of FMDV, type O. We felt that there is a need especially for quantitative data on genetic relationships between different subtypes, because the serological classification is not always congruent with a classification based on immunological properties (Wittmann, 1964). Furthermore, it appeared interesting to compare in cross-annealing experiments wild-type virus with mutants reacting identically in serological tests.

The experiments were performed with radioactive labelled FMDV RNA of five O-subtypes and five mutants of subtype O1 which were hybridized with denatured unlabelled FMDV-specific double-stranded RNA of the respective virus-strains.

Received 20 December 1971; accepted 2 February 1972.




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Copyright © 1972 by the Society for General Microbiology.