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J Gen Virol 16 (1972), 127-134; DOI 10.1099/0022-1317-16-2-127
© 1972 Society for General Microbiology
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Haemagglutinin Relationships of Hong Kong(H3) and Asian(H2) Influenza Strains Delineated by Antigen-Specific Recombinants

W. R. Dowdle*, W. M. Marine{dagger}, Marion Coleman* and Violeta Knez{ddagger}

* The World Health Organization International Influenza Center for the Americas and the Respiratory Virology Unit, Center for Disease Control, Health Services and Mental Health Administration, Public Health Service, U.S. Department of Health, Education, and Welfare, Atlanta, Georgia 30333
{dagger} Department of Preventive Medicine and Community Health, Emory University School of Medicine, Atlanta, Georgia, U.S.A.

Reports by others have described the haemagglutinins of Hong Kong (H3N2) strains and the Asian (H2N2) strains as being antigenically unrelated. Cross reactions seen by the haemagglutination-inhibition (HI) test have been attributed to antibodies to a second major surface antigen, the neuraminidase, which is common to both subtypes. However, observations on human anamnestic antibody responses suggest the two haemagglutinins are related. In the present study we reexamined the antigenic relationship of these viruses using haemagglutinin specific virus recombinants, chicken and ferret antisera, antibody equilibrium filtration methods, and cross-infection in ferrets. Data from these studies consistently demonstrated an asymmetric relationship, independent of the neuraminidase, between the H2 and H3 strains.

{ddagger} Present address: Instituto de Virologia, Cordoba, Argentina.

Reprint requests to Dr W. R. Dowdle, Center for Disease Control, Atlanta, Georgia 30333, U.S.A.

Received 7 February 1972; accepted 28 March 1972.




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Copyright © 1972 by the Society for General Microbiology.