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The Production of Interferon in Chick Cells Infected with DNA Viruses: A Search for Double-stranded RNA

Department of Biological Sciences Warwick University Coventry CV4 7AL England

Double-stranded RNA has been widely regarded as the inducer of interferon formation, both in virus-infected cells and in cells treated with synthetic polynucleotides (Colby, 1971). It is not difficult to see how infection with RNA viruses may lead to the formation of double-stranded RNA, but how do DNA viruses induce interferon formation? Colby & Duesberg (1969) have isolated a double-stranded RNA from chick cells infected with vaccinia virus, and shown that this double-stranded RNA induced interference against a virus challenge. However, they did not measure interferon production, either by virus infected cells or by the cells treated with double-stranded RNA, and since were found that chick cells infected by vaccinia virus did not produce interferon, there was some doubt about their explanation.

^* On leave from the Institute of Microbiology, University Medical School, Szeged, Hungary.

Received 12 April 1972; accepted 2 June 1972.