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J Gen Virol 18 (1973), 237-246; DOI 10.1099/0022-1317-18-3-237
© 1973 Society for General Microbiology
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Specificity of Interferon-induced Enhancement of Toxicity for Double-stranded Ribonucleic Acids

W. E. Stewart, II, E. de Clercq and P. de Somer

Rega Institute for Medical Research, University of Leuven, Leuven, Belgium

Interferon-treated cells exhibited an increased susceptibility to the toxicity of several natural and synthetic double-stranded RNA molecules and to vaccinia virus, provided the latter was able to undergo replicative events. However, interferon-treated cells exhibited no enhanced susceptibility to several other toxic materials or to vaccinia virus that was unable to replicate. These findings suggest that interferon-treated cells exhibit a specific enhanced susceptibility to the toxicity of double-stranded RNA molecules. Since neither RNA nor protein synthesis was required for toxicity to occur in interferon-treated cells exposed to polyriboinosinic-polyribocytidylic acid, it appears that the double-stranded RNA configuration is directly lytic for interferon-treated cells.

Received 14 August 1972; accepted 12 October 1972.


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