J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 18 (1973), 393-397; DOI 10.1099/0022-1317-18-3-393
© 1973 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tálas, M.
Right arrow Articles by Szolgay, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tálas, M.
Right arrow Articles by Szolgay, E.
Agricola
Right arrow Articles by Tálas, M.
Right arrow Articles by Szolgay, E.

Interferon, Nucleic Acid and Protein Synthesis in Mouse Spleen Cells after Acute {gamma}-Irradiation

Margarita Tálas*,§, Irina Konstantinova{dagger}, B. B. Fuks{ddagger}, Ivana Stöger* and Erika Szolgay*

* Microbiological Research Group of the Hungarian Academy of Sciences Budapest, Hungary
{dagger} Institute of Medico-Biological Problems Moscow, USSR
{ddagger} Institute of Morphology of Man Moscow, USSR

There is evidence that the spleen is one of the main sites of interferon synthesis (Heineberg, Gold & Robbins, 1964; Kono & Ho, 1965; Fruitstone et al. 1966). Other studies have shown that the role of the spleen is more important in the production of interferon in response to intravenously administered endotoxin than in the synthesis of virus-induced interferon (De Somer & Billiau, 1966; Borecky & Lackovic, 1967; Ito et al. 1971). Effects of X-irradiation and antilymphocyte serum on the levels of circulating interferon prompted the conclusion that peripheral blood lymphocytes take part in myxovirus-induced interferon production (De Maeyer, De Maeyer-Guignard & Jullien, 1969; De Maeyer-Guignard & De Maeyer, 1971).

We have shown previously that although acute or fractional X- or {gamma}-irradiation or acute proton irradiation causes a reduction in spleen weight, the synthesis of circulating interferon does not change, and sometimes even increases, when poly I:C or endotoxin was used as inducer (Tálas et al. 1971, 1972a, b).

§ Present address: Department of Virology and Epidemiology, Baylor College of Medicine, Texas Medical Center, Houston, Texas 77025, U.S.A.

Received 21 August 1972; accepted 30 November 1972.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1973 by the Society for General Microbiology.