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Oncogenicity of Non-transforming Mutants of Avian Sarcoma Viruses

Houghton Poultry Research Station Houghton, Huntingdon, England

T. Graf

Department of Microbiology and Immunology Duke University Medical Center Durham North Carolina 27710 U.S.A.

H. Bauer

Abteilung Virologie Robert Koch-Institut 1, Berlin 65 Nordufer 20 W. Germany

For practical purposes avian RNA tumour viruses have been divided into sarcoma and leukosis viruses. Sarcoma viruses have the ability to transform chick embryo fibroblasts in vitro and to induce fibro-sarcomas in vivo after a latent period of about 7 to 21 days. Leukosis viruses do not transform chick embryo fibroblasts, although they replicate in them, and in vivo most wild strains induce principally lymphoid leukosis after a latent period of over 90 days. They also frequently induce erythroid leukosis (erythroblastosis) and osteopetrosis, and occasionally other tumours.

Non-transforming mutants of sarcoma viruses, which have all the in vitro properties of leukosis viruses, have been produced experimentally by exposure to ultraviolet light (Toyoshima, Friis & Vogt, 1970), by -irradiation (Goldé, 1970) and by treatment with chemicals (Graf et al. 1971). These results suggest that leukosis viruses may originate from sarcoma viruses, perhaps by loss of genetic material either by mutation or by segregation of subgenomic components (Toyoshima et al. 1970; Graf et al. 1971; Martin & Duesberg, 1972).

Received 19 June 1972; accepted 1 December 1972.