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Host Range Conversion of the Murine Sarcoma-leukaemia Complex

Department of Oncology, Institute of Medical Science, University of Tokyo, P.O. Takanawa, Tokyo, Japan

Infection by N- or B-tropic murine sarcoma virus (MSV) ‘pseudotypes’ in the presence of murine leukaemia virus (MLV) of the opposite tropism to non-permissive cells of the MSV resulted in about a 100- to 1000-fold increase of focus formation in comparison with MSV solitary infection. The culture fluid of such mixedly infected cells contained MSV ‘pseudotypes’ whose tropism was identical to that of MLV.

Received 15 December 1972; accepted 18 January 1972.