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The Serological Relationship of the Soluble Antigens of Adenovirus Type 19^*

A. Lengyel

Institut für Hygiene und Mikrobiologie der Universität des Saarlandes, Homburg (Saar), Germany

The relationship of group-specific (hexon) antigen, type-specific (fibre) antigen, soluble haemagglutinin (dodecon) and purified virus particles of adenovirus 19 was studied by cross complement-fixation, haemagglutination-inhibition and neutralization with antisera prepared against purified antigens. The fibre antigen reacted as an indirect haemagglutinin, producing haemagglutination in the presence of selected heterologous adenovirus immune sera. Dodecon and fibre antigen were closely related, while hexon antigen showed no relationship to fibre and possibly a weak relationship to dodecon antigen. Neutralizing antibodies were found in antisera to hexon and dodecon, but not in fibre antisera.

^* Aided by a grant from The Deutsche Forschungsgemeinschaft.

Having worked in Homburg on a fellowship of the World Health Organization. Present address; Institute for Microbiology, Medical Faculty, University of Budapest, Hungary.

Received 14 August 1967; accepted 6 November 1967.