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J Gen Virol 2 (1968), 445-449; DOI 10.1099/0022-1317-2-3-445
© 1968 Society for General Microbiology
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Influence of Animal Genotype and Age on the Amount of Circulating Interferon Induced by Newcastle Disease Virus

E. De Maeyer and Jaqueline De Maeyer-Guignard

Institut du Radium Biologie, Orsay, 91, France

Following the paper by Baron & Buckler (1963) describing the release of interferon (Isaacs & Lindenmann, 1957) into the blood of mice injected with viruses, extensive use has been made of this experimental procedure to study various aspects of interferon synthesis in vivo. The usual criterion for selecting animals for such experiments has been to use those within a narrow weight range in random-bred strains. During an investigation on the effect of carcinogens on interferon synthesis in mice (De Maeyer & De Maeyer-Guignard, 1967) we noticed that the amounts of circulating interferon in animals injected with Newcastle disease virus varied with animal age and strain. This observation led to more systematic experiments which are reported here.

Mice belonged to three strains. C3H/He and C57Bl mice were purchased from the Laboratory Animal Centre (M.R.C., Carshalton, Surrey, England). Only the first and second generations derived from the Carshalton breeder mice were studied.

Received 16 October 1967; accepted 15 December 1967.


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J. De Maeyer-Guignard
Mouse Leukemia: Depression of Serum Interferon Production
Science, September 1, 1972; 177(4051): 797 - 799.
[Abstract] [PDF]


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