J Gen Virol
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J Gen Virol 2 (1968), 469-472; DOI 10.1099/0022-1317-2-3-469
© 1968 Society for General Microbiology
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Analysis of Nearest Neighbour Base Frequencies in the RNA of a Mammalian Virus: Encephalomyocarditis Virus

J. Hay* and H. Subak-Sharpe

Institute of Biochemistry M.R.C. Unit for Experimental Virus Research Institute of Virology University of Glasgow, Scotland

The technique of frequency analysis of nearest neighbour base sequences in DNA (Josse, Kaiser & Kornberg, 1961) allows the characterization and description of a DNA in terms of the average frequency of occurrence of its sixteen possible doublet sequences. This technique has recently been used to study the patterns of doublet frequencies before and after normalization in the DNA of nine mammalian viruses (Subak-Sharpe, et al. 1966; Morrison et al. 1967; Subak-Sharpe, 1967). It was found that the doublet pattern in the DNA of the four small oncogenic viruses studied resembled the pattern in the host DNA to a remarkable extent, whereas the five large viruses investigated showed virtually no similarity to the host pattern.

The authors reasoned a priori that a cell's translation apparatus, being the result of natural selection, would have a population of transfer RNAs adapted optimally to translate the polypeptide-specifying sequences of the cell DNA.

* At present on leave at the Department of Biochemistry, College of Physicians and Surgeons of Columbia University, New York, New York 10032.

Received 12 February 1968; accepted 21 February 1968.




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Copyright © 1968 by the Society for General Microbiology.