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Replication of Rhinovirus RNA

Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, Warwickshire, England

We have studied the synthesis of virus RNA in human embryo lung cells infected with rhinovirus type 2. The three species of RNA in extracts of infected cells are, in order of decreasing electrophoretic mobility, single-stranded RNA, replicative form and replicative intermediate. The kinetics of synthesis of these RNA species were investigated. The electrophoresis of mixtures of single-stranded RNA synthesized early and late in infection showed no differences in size. This observation was confirmed with a bovine enterovirus. The native form of poliovirus type 1 single-stranded RNA migrated faster on polyacrylamide electrophoresis than rhinovirus single-stranded RNA.

Received 7 August 1972; accepted 5 February 1973.

This article has been cited by other articles:

				K. Gerber, E. Wimmer, and A. V. Paul Biochemical and Genetic Studies of the Initiation of Human Rhinovirus 2 RNA Replication: Purification and Enzymatic Analysis of the RNA-Dependent RNA Polymerase 3Dpol J. Virol., November 15, 2001; 75(22): 10969 - 10978. [Abstract] [Full Text] [PDF]