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J Gen Virol 20 (1973), 139-149; DOI 10.1099/0022-1317-20-2-139
© 1973 Society for General Microbiology
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The Mechanism of Interferon Action in Single Cells: accumulation of Intracellular Virus*

Tze-Ta Chang{dagger}, E. H. Simon and W. R. Fleischmann, Jun.{ddagger}
Accumulation of intracellular mengovirus was studied in single, isolated mouse L cells. Pre-treatment with interferon delayed the initiation of virus replication in most cells, with the amount of delay varying widely from cell to cell. However, once the accumulation of intracellular virus began, it proceeded at an approximately normal rate. The data suggest that within a cell at any given moment, the action of interferon is usually all or nothing. That is, virus production is either totally inhibited, or free to proceed normally.

* Supported by grant no. GB 12623 from the National Science Foundation.

{dagger} Parts of this work were submitted in partial fulfillment of M.S. degree.

{ddagger} Predoctoral fellow of the National Institutes of Health. Present address: Department of Microbiology, Indiana University.

Received 11 October 1972; accepted 2 March 1973.


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