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J Gen Virol 20 (1973), 169-175; DOI 10.1099/0022-1317-20-2-169
© 1973 Society for General Microbiology

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Determinants of the Host Range of Feline Leukaemia Viruses

O. Jarrett, Helen M. Laird and D. Hay

University of Glasgow, Leukaemia Research Unit, Bearsden, Glasgow, Scotland G61 1QH

Feline leukaemia viruses of subgroups B and C multiply in human and canine cells, while subgroup A viruses do not. This host range restriction is determined by the virus envelope and operates at the level of virus entry into the cell. Subgroup A virus genomes are expressed and replicated when they are introduced within B subgroup envelopes into human or dog cells. Therefore, since they are phenotypic mixtures of A and B subgroup viruses, the majority of feline leukaemia virus isolates will infect human and canine cells with the subsequent production of FeLV of each subgroup.

Received 14 February 1973; accepted 8 March 1973.


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