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Size Differences in the Ribonucleic Acids of Feline Leukaemia Viruses

Leukaemia Research Unit, University of Glasgow, Bearsden, Glasgow G61 1QH, Scotland

Electrophoretic analysis of native and denatured RNA of feline leukaemia virus (FeLV) has revealed small but significant size differences between the RNAs of a number of FeLV isolates. The mol. wt. of the denatured or subunit RNA has been estimated to range from 2·2 to 2·6 x 10⁶ in the different isolates, each of which belonged to one or more FeLV subgroups (A, B and C). The RNA of subgroup A virus was smaller than that of subgroup B virus, while the RNA of subgroup C virus appeared to be intermediate in size between the RNAs of A and B subgroup viruses. Size differences were, however, also found between RNAs of FeLV isolates of a single subgroup (A), indicating that no simple relationship exists between RNA size and virus subgroup.

Received 6 March 1973; accepted 14 May 1973.

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