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Inhibition by Interferon of Polyoma Virus-induced Cell DNA Synthesis in Mouse Peritoneal Macrophages

Department of Microbiology, Guy's Hospital Medical School, London Bridge, London, S.E.1, U.K.

Joyce Taylor-Papadimitriou

Theagenion Cancer Institute, Thessaloniki, Greece

Mouse peritoneal macrophages from C57 Bl and NIH mice were examined after infection with polyoma virus. Cell DNA synthesis was stimulated in both cell types to the same extent between two and three days after addition of virus. Morphological changes appearing soon after infection were reversed by the second or third day. The cells did not acquire other properties associated with the transformed state. Treatment with mouse interferon up to 48 h after infection inhibited the virus-induced host DNA synthesis while morphological changes were not affected.

Received 24 January 1973; accepted 3 July 1973.