HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sethi, K. K. Articles by Brandis, H. Search for Related Content PubMed PubMed Citation Articles by Sethi, K. K. Articles by Brandis, H. Agricola Articles by Sethi, K. K. Articles by Brandis, H.

Cytochalasin B-induced Activation in the Synthesis of L-cell Virus Particles

Institutes of Medical Microbiology, Immunology and Parasitology, University of Bonn 53 Bonn-Venusberg, West Germany.

Some but not all of the mouse L cell strains carry virus particles which have been found to be morphologically, biochemically and antigenically indistinguishable from known RNA tumour viruses. Present electron microscopic study has revealed that cultures of two of the clones derived from NCTN 929 cells when grown in Eagle's medium enriched with foetal calf serum contained a few intracisternal A-type virus-like particles but were continuously negative for C-type virus particles. Exposure of the cultures to the drug cytochalasin B resulted in the appearance of abundant intracytoplasmic and extracellular C-type virus particles. Possible mechanisms of the activation of virus synthesis and release by cytochalasin B are discussed.

Received 12 June 1973; accepted 2 July 1973.