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An Isatin -thiosemicarbazone (IBT)-dependent Mutant of Vaccinia Virus: The Nature of the IBT-dependent Step

Department of Virology, The Hebrew University — Hadassah Medical School, Jerusalem, Israel

The IBT-dependent mutant of vaccinia virus needs IBT for its growth. IBT is not essential for the synthesis of virus DNA, but the formed DNA does not become resistant to deoxyribonuclease in its absence. Both ‘early’ and ‘late’ virus proteins are synthesized in cells infected with the mutant, but in the absence of IBT one of the virus core structural polypeptides, which is normally formed from a higher mol. wt. precursor, is not made. These findings suggest that the IBT-dependent step of the mutant occurs earlier in the maturation process of the virus than does the block produced by IBT with the wild-type strain.

Received 5 June 1973; accepted 25 July 1973.