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National Institute for Medical Research Mill Hill London, N.W.7, U.K.
Electron microscopy of L cells infected with vaccinia virus at a high multiplicity indicated that virus cores entered the cytoplasm, during a 15 min period of adsorption at 37 °C, as a result of fusion between the plasma membrane and the envelopes of virus particles. It is suggested that for vertebrate poxviruses this, rather than phagocytosis, could be the effective mode of entry leading to infection.
Received 19 July 1973;
accepted 16 August 1973.
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