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Absence of Adenovirus-specific Repressor in Adenovirus Tumour Cells

Départment de Microbiologie Centre Hospitalier Universitaire, Sherbrooke, Québec, Canada

Sendai virus mediated fusion of adenovirus type 12 (Ad. 12) transformed cells (HTC) and permissive cells (HEp-2) was used to (i) rescue Ad. 12, (ii) determine if a repressor is present in the HTC cells. No evidence of virus rescue was observed. The presence of repressor in the transformed cells was tested by superinfecting heterokaryocytes of HTC and HEp-2 cells, with Ad. 12. Inclusion bodies and virus antigens were observed in both types of nuclei of heterokaryocytes demonstrating the absence of Ad. 12 specific repressor in the HTC cells.

Received 13 August 1973; accepted 8 October 1973.