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Effects of Adsorption of u.v.-inactivated Parainfluenza (Sendai) Virus on the Incorporation of Amino Acids in Animal Host Cells

Israel Institute for Biological Research and Tel-Aviv University Medical School, Ness-Ziona, Israel.

Following the adsorption of u.v.-inactivated Sendai virus at high multiplicity on to HeLa-S3 or L-929 cells there was a transient inhibition of uptake of amino acids into the cells, but no inhibition of protein synthesis. The uptake of amino acids into virus-treated cells was maximally inhibited at the end of the adsorption period, but within a few hours returned to control level.

The changes in the uptake of amino acids occurred concomitantly with enhanced potassium uptake and with inhibition of DNA synthesis, but were of longer duration.

Received 11 July 1973; accepted 12 October 1973.