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J Gen Virol 22 (1974), 293-296; DOI 10.1099/0022-1317-22-2-293
© 1974 Society for General Microbiology
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Effects of Actinomycin D on Early Steps of Replication in vitro of Murine Sarcoma Virus (Moloney)

Chantal Godard, Jacqueline Robin and M. Boiron

Laboratoire d'Hématologie Expérimentale Institut de Recherches sur les Maladies du Sang Hôpital Saint-Louis, 2, place du Docteur A. Fournier 75475 Paris Cedex 10 - France

The sensitivity to actinomycin D of the early steps of the in vitro replication of murine sarcoma virus (Moloney) (M-MSV) was investigated by treating infected mouse cells with the antibiotic (0.25 µg/ml) for 6 h periods at several times after infection. The results obtained indicate that M-MSV production is inhibited when actinomycin D is added within 21/2 h of infection.

Received 26 July 1973; accepted 25 October 1973.




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