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J Gen Virol 22 (1974), 437-440; DOI 10.1099/0022-1317-22-3-437
© 1974 Society for General Microbiology
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Interfering Particles from a Culture Persistently Infected with Parana Virus

L. D. Staneck*

Department of Microbiology University of Massachusetts, Amherst, Massachusetts

C. J. Pfau

Department of Biology Rensselaer Polytechnic Institute, Troy, New York 12181, U.S.A.

The existence of defective interfering (DI) particles has been well documented for a number of virus systems (Huang & Baltimore, 1970). Such particles are currently of great interest since their ability to cause homologous interference has been implicated as a possible regulatory factor in the establishment of chronic or persistent virus disease (Huang & Baltimore, 1970). We have recently reported that about 50 cell generations after infection of BHK 21/13S cells with either lymphocytic choriomeningitis virus (LCMV) or Parana virus, infective virus could no longer be detected in either the cells or the culture medium (Staneck et al. 1972). However, LCMV-infected cultures continued to produce particles with an interference activity which closely resembled DI virus (Welsh, O'Connell & Pfau, 1972). The data presented here indicate that Parana, another arenavirus (Rowe et al. 1970), can initiate the nearly exclusive synthesis of DI virus under the same conditions.

* Present address: Department of Microbiology, Mayo Medical School, Mayo Foundation, Rochester, Minnesota 55901, U.S.A.

Received 16 July 1973; accepted 14 November 1973.




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Copyright © 1974 by the Society for General Microbiology.