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Relationship of Cytotoxicity and Interferon-inducing Activity of Polyriboinosinic Acid. Polyribocytidylic Acid to the Molecular Weights of the Homopolymers

Department of Virology, Rega Institute for Medical Research, University of Leuven, B-3000 Leuven, Belgium

The molecular size of poly I.poly C required for lysis of interferon-treated L cells was the same as the size required for induction of interferon in these cells. The size requirement for both interferon induction and toxicity for interferon-treated L cells resided in the poly I strand, while variations of the poly C strand size were without effect on interferon induction or cell lysis.

The size of poly I.poly C required to induce interferon in primed L cells or primed primary rabbit kidney cells was the same as the size required to induce interferon in normal L cells or normal rabbit kidney cells. Again, these requirements proved more stringent for the poly I strand than for the poly C strand. These data suggest that both primed and normal cells recognize the same molecular ‘trigger’ for interferon induction.

Received 8 November 1973; accepted 28 November 1973.

This article has been cited by other articles:

				H. B. Levy Review : Polynucleotides as Interferon Inducers and Immune Modulators Journal of Bioactive and Compatible Polymers, July 1, 1986; 1(3): 348 - 385. [PDF]