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Evidence for the Temporal Regulation of Protein Synthesis in Synchronized Bacteriophage X174 Infections

Biology Department, Marquette University Milwaukee, Wisconsin 53233, U.S.A.

Virus-specific protein synthesis has been studied in unsynchronized and in starvation-synchronized infections of u.v.-irradiated su^- host cells by X174wt and a set of X conditional lethal mutants. Several virus-specific protein species were detected in association with the host cell membrane at various times during the virus reproduction cycle; virus-specific proteins were also detected in the host cell cytoplasm. The intracellular distribution, between the cell membrane fraction and the cell cytoplasm fraction, of virus proteins was measured under a variety of experimental conditions. The possible significance of the presence of virus proteins on the host cell membrane is discussed.

^* Present address: Frederick Cancer Research Center, P.O. Box B, Frederick, Md. 21701, U.S.A.

Received 15 October 1973; accepted 1 February 1974.