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J Gen Virol 23 (1974), 331-333; DOI 10.1099/0022-1317-23-3-331
© 1974 Society for General Microbiology
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Necessity for the 2'-Hydroxyl Group for the Antiviral Activity of Synthetic Polynucleotides

D. W. Hutchinson and M. D. Johnston

Departments of Molecular and Biological Sciences University of Warwick Coventry CV4 7AL Warwickshire England

M. A. W. Eaton

Searle Research Laboratories Lane End Road High Wycombe HP12 4HL England

Hybrids from poly dI and poly r(5-halogenocytidylic acids) having Tm's in the region of 60 °C are inactive as interferon inducers thus confirming the requirement for a free 2'-hydroxyl group in both the poly I and poly C strands of poly rI.poly rC.

Received 18 December 1973; accepted 12 February 1974.




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Copyright © 1974 by the Society for General Microbiology.