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Inhibition of Rhinovirus RNA Synthesis in Diploid Cells by a Substituted Guanidine Compound having a different Mode of Action from Guanidine

Department of Biological Sciences University of Warwick, Coventry Warwickshire CV4 7AL, England

The compound ICI 65,709 is a substituted guanidine which has antiviral activity in human embryo lung cells (Bucknall et al. 1973). We have found that ICI 65,709 reversibly inhibits the synthesis of RNA by rhinovirus type 2. The three species of virus RNA were equally affected. Comparison of the effect with that of guanidine, a well known inhibitor of picornavirus RNA synthesis, showed that ICI 65,709 and guanidine mediated their antiviral effects in different ways. This conclusion was supported by the failure of ICI 65,709 to inhibit multiplication of a bovine enterovirus which was inhibited by guanidine. ICI 65,709 also inhibited the multiplication of poliovirus type 1.

Received 14 September 1973; accepted 22 February 1974.