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J Gen Virol 24 (1974), 237-246; DOI 10.1099/0022-1317-24-2-237
© 1974 Society for General Microbiology
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Abortive Infection and Transformation of Human Embryonic Fibroblasts by Molluscum contagiosum Virus

G. Barbanti-Brodano, A. Mannini-Palenzona, O. Varoli, M. Portolani and M. La Placa

Istituto di Microbiologia, Università di Bologna, Bologna, Italy

Abortive transformation of human embryonic fibroblasts was induced by Molluscum contagiosum virus. The parameters studied in order to test the establishment of a persistent infection and transformation of cells were: (1) virus interference and interferon production; (2) alterations of cell morphology and growth; (3) presence of neoantigens; (4) karyotype. The possible mechanisms leading to an abortive transformation are discussed.

Received 12 November 1973; accepted 14 March 1974.




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