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Deoxyglucose Transport Changes in Murine Sarcoma Virus-infected Cells — a Quantitative Assay for Virus Transforming Activity

Department of Microbiology St Louis University School of Medicine, St Louis, Missouri 63104 U.S.A.

Dose-response studies were performed in relation to the rate of uptake of [³H]-2-deoxyglucose by murine sarcoma virus-infected murine cells. A linear relationship was observed between the virus dilution used for infection and the rate of dgl uptake by the infected cells. The extrapolated dilution factor (reciprocal of dilution) at which no difference was observed between infected and uninfected cells was directly proportional to the activity estimated by focus assay of MSV. Such end-point dilution factors can be reproducibly and objectively obtained 2 to 4 days after infection.

^* To whom all correspondence should be directed.

Received 22 January 1974; accepted 18 April 1974.