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Interferon Induction by Single-stranded Polynucleotides Modified with Polybases

Departments of Medicine and Microbiology, The Johns Hopkins University School of Medicine, Oncology Center Baltimore City Hospitals, Baltimore, Maryland, U.S.A.

J. Pitha

The Laboratory of Molecular Aging, National Institutes of Health National Institute of Child Health and Human Development Gerontology Research Center Baltimore City Hospitals, Baltimore, Maryland, U.S.A.

Single-stranded polynucleotides (poly I and poly C), which do not generally have antiviral activity, became effective inducers of interferon when aggregated with different polycations. Poly I was consistently more active than poly C. The biological activity of the complexes depended more on the nature of the polycationic component than on the presence of the complementary base residue: introduction of covalently bound cytosine residue into the poly I—polybase complex did not have any significant effect.

Received 10 January 1974; accepted 26 April 1974.