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Pericentriolar Virus-like Particles in Chinese Hamster Ovary Cells

Department of Pathology University Medical Buildings, Foresterhill, Aberdeen AB9 2ZD, Sotland>

Virus-like particles have been found closely associated with the centrioles in CHO-K1 and CHO-10 cells but not in other cell lines. They are spherical and measure 55 to 65 nm in overall diam.; their central cores of about 35 to 40 nm diam. sometimes appear hollow and sometimes dense. An amorphous matrix similar to that surrounding the centrioles is found around the particles. The possibility that they represent a type-A virus is discussed.

Received 21 March 1974; accepted 3 May 1974.